Leicester City will face Napoli, Poland's Legia Warsaw and Spartak Moscow in the Europa League this season after being drawn in Group C on Friday.
City's Premier League rival West Ham United, which is making its group-stage debut in the competition, was handed trips to Croatia, Belgium and Austria after being drawn against Dinamo Zagreb, Genk and Rapid Vienna in Group H.
PSV Eindhoven, runner-up in the Dutch top flight last season, was placed in a tough Group B, which also includes AS Monaco, Spain's Real Sociedad and Austrian side Sturm Graz.
Scottish champions Rangers were drawn in Group A, where they will play France's Olympique Lyonnais, Czech side Sparta Prague and Danish club Brondby, while Celtic are in Group G alongside Bayer Leverkusen, Real Betis and Ferencvaros.
The 2021/22 Europa League group stage is set!
— UEFA Europa League (@EuropaLeague) August 27, 2021
This season's competition involves 32 teams, down from 48 last season, but will have an extra knockout round before the last-16 stage.
European soccer's governing body UEFA has also scrapped the away goals rule, with the winners of each two-legged group tie to be decided by extra time and penalties if level on aggregate.
The Europa League final will be held at Seville's Ramon Sanchez Pizjuan stadium on May 18, with the group stages scheduled to start on Sept. 16.
In the Europa Conference League, Tottenham was grouped with Rennes, Vitesse and Mura.
The 2021/22 Europa Conference League group stage
— UEFA Europa Conference League (@europacnfleague) August 27, 2021
The following is the draw for the Europa League group stage, which took place in Istanbul on Friday.
Europa League 2021 Group Stage Draw
Group A: Olympique Lyonnais, Rangers, Sparta Prague, Brondby
Group B: AS Monaco, PSV Eindhoven, Real Sociedad, Sturm Graz
Group C: Napoli, Leicester City, Spartak Moscow, Legia Warsaw
Group D: Olympiakos Piraeus, Eintracht Frankfurt, Fenerbahce, Royal Antwerp
Group E: Lazio, Lokomotiv Moscow, Olympique de Marseille, Galatasaray
Group F: Braga, Red Star Belgrade, Ludogorets, Midtjylland
Group G: Bayer Leverkusen, Celtic, Real Betis, Ferencvaros
Group H: Dinamo Zagreb, Genk, West Ham United, Rapid Vienna
Europa Conference League 2021 Group Stage Draw
Group A: Lask, Maccabi Tel-Aviv, Alashkert, HJK Helsinki
Group B: Gent, FK Partizan, Flora, Anorthosis
Group C: Roma, Zorya Luhansk, CSKA Sofia, Bodo/Glimt
Group D: AZ Alkmaar, CFR Cluj, Jablonec, Randers
Group E: Slavia Prague, Feyenoord, Union Berlin,
Group F: Copenhagen, PAOK, Slovan Bratislava, Lincoln Red Imps
Group G: Tottenham, Rennes, Vitesse, Mura
Group H: Basel, Qarabag, Kairat, Omonoia
(Reporting by Simon Jennings in Bengaluru; Editing by Ken Ferris)